TESTING FOR CANCER HAS NEVER BEEN EASIER.
The prime concern of a doctor after diagnosis, is drawing out the best possible treatment that leads to the least side effects in the patient. The challenge is to attain that balance. Therefore, pathological tests for diagnosis and selecting the most appropriate choice of antibiotics for precise treatment has been used as the standard practice in treating infectious diseases.
In cancer treatment however, the traditional method for identifying the mutation causing the cancer has been through biopsies, which involve invasive surgical procedures through which tissue samples are extracted from a patient's tumour. However, it is not possible to obtain such samples if the patient is inoperable or the tumour is located in a risky area, as in case of recurrences in brain and other regions. Dr. A.V.S. Suresh, an Oncologist with Continental Hospitals, Hyderabad, tells us about the advanced technique called Next Gen Sequencing (NGS).
NGS has made it possible to map the genomic makeup of a cancer tumour and identify personalised treatment options with just a blood test. It uses the tumour DNA to predict the tumour sensitivity based on analysis of existing mutations in the cancer development pathway. It also highlights the possible side effects of various therapies based on the genetic makeup of a given patient. Known as 'liquid biopsies', these tests fuel hopes of better treatment options for patients and are an integral aspect of precision medicine.
The ability to assess genomic markers that are included in various international guidelines like NCCN (National Comprehensive Cancer Network), FDA and information on sensitivity, resistance and toxicity to relevant approved therapies for solid tumour treatment makes NGS a potent tool in detecting many recurrent diseases.
Dr. Suresh says, "This is a great step in improving the quality of life of terminally ill patients. If made available widely at an affordable price, I am sure this will become a handy tool for Oncologists and will help cancer patients".
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